Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease that is associated with poor prognosis. Recent works have revealed the significant roles of miRNA in ccRCC initiation and progression ...
这说明肿瘤细胞所处的微环境(“土壤”)对其基因表达有重要影响。同时,研究还发现了一些与肿瘤转移相关的特定功能基因和信号通路,比如在肝脏定植后,Tufm 和 Atp1b1 等基因上调,而在肺中,Sftpc、Bak1 等基因被激活促进细胞生长。 肿瘤细胞与 TME 的通讯 ...