Specifically, paeonol significantly reduced the protein levels of ADAMTS5 and MMP13 promoted by IL-1β, and this inhibitory effect was partially reversed by Erastin. This phenomenon was further ...

免疫印迹还表明，抑制 miR-103-3p 可下调 ADAMTS5 和 MMP13 蛋白水平，上调胶原蛋白 II（collagen II）和聚集蛋白聚糖（aggrecan）水平，减少 ECM 大分子降解。 过表达 miR-103-3p 对软骨细胞的影响：qPCR 结果表明，miR-103-3p 模拟物可显著提高 IL-1β 刺激的软骨细胞中 miR-103-3p ...

MicroRNAs (miRNAs) are critical regulators of the skeleton. In the growth plate, these small non-coding RNAs modulate gene networks that drive key stages of chondrogenesis, including proliferation, ...

而不同浓度的 SDF-1 处理 OA 软骨细胞后，100ng/ml 的 SDF-1 能够显著增加聚集蛋白聚糖（aggrecan，软骨合成代谢的标志物）的表达，抑制基质金属蛋白酶 13（MMP-13）和含血小板凝血酶敏感蛋白基序的解聚蛋白样金属蛋白酶 5（ADAMTS5，二者均为软骨分解代谢的标志物 ...

Cardiac fibrosis, a hallmark of heart failure and various cardiomyopathies, represents a complex pathological process that has long challenged therapeutic intervention. High-throughput omics ...