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重大突破!RNA 与肼反应性研究新发现:为 RNA 修饰检测开辟前沿路径
s4U 和 D 中 C4 作为亲电体与肼反应, 与氢氧根离子(或羟基自由基)反应形成 N7 - 甲基 - FAPy - G。 研究结论与讨论 这项研究表明,无苯胺肼化学可与至少 8 种修饰核苷发生反应,且 RNA 磷酸二酯键保持完整。优化后的反应条件能使 RNA 中尿苷的破坏率高达 90% ...
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今日热点
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