Screening millions of chemical compounds to identify the candidates for drug development ... most of the protein molecular binding energy. It is essential to discover the epitope peptides for ...

“There is great need to revolutionize the current inefficient drug discovery ... target’s protein, where it analyzes the surface and creates multiple smart grids that depict binding-related ...

E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...

Peptides act as signal mediators in the body and are on the rise as therapeutic agents. However, their full potential can ...

Two separate research teams have found ways to create short chains of amino acids, termed peptides, for the purpose of ...

their high efficiency allows for lower doses of drugs, potentially reducing the side effects. "Peptides, which are designed molecules made from the same building blocks as the proteins in our body ...

A relatively simple peptide modification could unlock a whole class of targets for drug discovery ... These proteins are attractive targets because they have well defined "binding sites" for ...

Knowledge of the ligand-binding regions is also extremely valuable for structure-based drug design and biological ... to directly generate small peptides from native proteins.

their high efficiency allows for lower doses of drugs, potentially reducing the side effects. "Peptides, which are designed molecules made from the same building blocks as the proteins in our body ...

Current research in the Moore Lab includes engineering proteins for diagnosing and treating cancer, and developing methods to enable protein therapeutics to access drug ... Binding Agents.”Methods in ...

The process involved: Optimizing the β-catenin protein structure to improve the binding interface ... development of orally available cyclic peptide drugs, potentially transforming the ...