In this study, we investigated the dynamics of the β-cell and α-cell function and mass in pancreas of obese normoglycemic baboons. Relative α-cell volume (RαV) and relative islet α-cell ...

Replacement of β cells by islet transplantation is a novel therapy for diabetes, although a major obstacle has been the limited amount of islet tissue available. A rigorous demonstration of the ...

Objective—Somatostatin (SST) is secreted by islet δ-cells and by extraislet neuroendocrine cells. SST receptors have been identified on α- and β-cells, and exogenous SST inhibits insulin and ...

Mitochondria act as cellular power plants, converting nutrients into energy. When these structures fail, cells struggle to function properly. Their dysfunction has been tied to metabolic disorders, ...

A recent study released by researchers from Pohang University of Science and Technology (POSTECH) opens the door for more effective diabetes research and treatment. The new approach leverages ...

α/β/δ GFP-labeled mice of different ages were treated with HFD or STZ in order to create the diabetic mouse model. There is no reciprocal identity change of mouse islet cells after HFD ...

Scientists headed by a team at the University of Utah Health have reported on research in mice suggesting that microbiome composition during infancy can shape development of pancreatic insulin ...

1 When released, GLP-1 activates its receptor, GLP-1R, in the pancreatic islet β cells, provoking a myriad of metabolic changes characterized by insulin secretion and appetite suppression.

There is now emerging evidence that male obesity negatively impacts male reproductive potential not only by reducing sperm quality, but in particular altering the physical and molecular structure of ...