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抑制组蛋白去乙酰化酶 6 缓解神经性疼痛的机制研究
研究结论和讨论部分指出,本研究表明 HDAC6 抑制剂 ACY-1215 可通过调节 STAT3 的翻译后修饰,减少其促炎信号,抑制 CCL7 产生,从而缓解神经性疼痛。这揭示了 HDAC6/STAT3/CCL7 信号轴在神经性疼痛中的重要作用,为治疗神经性疼痛提供了新的潜在靶点。不过,该研究也存在一定局限性,如仅在 SNI ...
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