The released E2F promotes the transcription of target genes involved in cell cycle progression. The pRB/E2F signaling pathway is controlled by DNA methyltransferase-1 (Dnmt-1). The elevated ...

In 1991 several groups, including our own, demonstrated that Rb forms a complex with the cellular transcription factor E2F. E2F contributes to the cell cycle-dependent transcription of a multitude of ...