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肝移植后胆管癌患者的化疗新解:DPYD 基因多态性检测的关键作用
然而,5-FU 在体内的代谢主要由肝脏中的二氢嘧啶脱氢酶(DPD)介导。DPD 活性不足时,患者长时间暴露于 5-FU,会引发危及生命的毒性反应。所以,评估 DPD 活性对接受 5-FU 化疗的癌症患者至关重要。 随着医疗技术的发展,肝移植手术越来越常见,特别是在胆管 ...
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