Many of the clonal analyses results of the cases in the discovery cohort had similar patterns to each other. We can posit two general clonal categories based on their dynamics across disease stages.

In particular, acute myeloid leukemia (AML) has been shown to undergo substantial clonal evolution over the course of the disease. AML tends to harbor fewer mutations than solid tumors ...

Study: Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis. Image Credit: BioFoto / Shutterstock ...