其中，Cre-loxP 系统（一种用于在生物体内实现条件基因重组的强大工具）备受瞩目。它能让研究者根据 loxP 序列的方向，对生物基因组中特定 DNA 位点（floxed site）进行删除、倒置或易位操作 ，进而深入研究遗传、发育、生理和疾病等过程中的分子和细胞机制。

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

The Irf8 floxed targeted mutated mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated.