Unfolded protein response: A key regulator of intestinal health and disease
Reduced XBP1 activity has been linked to poor survival outcomes in colorectal cancer patients, suggesting that UPR modulation ...
Nature6y
Mismanaged ER stress and inflammation
The unfolded-protein response (UPR) that is induced by this stress protects the cells, especially those with high secretory activity, from apoptosis. The transcription factor XBP1, which is ...