IntroductionHepatocellular carcinoma (HCC) is one of the deadliest cancers globally, with increasing incidence and mortality rates. It arises from ...

Thus, understanding the molecular mechanisms driving HCC is essential for developing new therapeutic strategies. A growing body of research highlights the crucial role of the Wnt signaling pathway, ...

Allarity Therapeutics, Inc. (“Allarity” or the “Company”) (NASDAQ: ALLR), a Phase 2 clinical-stage pharmaceutical company ...

By the late 1990s, scientists had managed to identify drugs that worked against mutant proteins that function in specific signaling pathways that cancer cells rely on—a step that ushered in a ...

"This work reveals how cancers can evade dependencies on Wnt signaling and serves as a ... resistant tumors by targeting the alternate cancer pathways unleashed by FBXW7 mutations," said Prof ...

Patient enrollment set to begin at leading U.S. clinical trial sites, new drug product already deliveredTrial will advance stenoparib and the ...

Dr. Gujral also works to develop better ways to screen potential cancer drugs. Noncanonical Wnt signaling pathway. Dr. Gujral’s lab explores how this pathway contributes to changes in cell state that ...

This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

Therapeutics announced that the new protocol for its Phase 2 clinical trial of stenoparib in ovarian cancer is set to begin and ...

Promising Liver Cancer Therapies such as Atezolizumab, Bevacizumab, Tiragolumab, OH2 injection, MTL-CEBPA, Sorafenib 200mg, ...