With a few exceptions, eukaryotic chromosomes have a single centromere that ensures their accurate segregation during mitosis. Chromosomes that lack centromeres segregate randomly during mitosis ...

At the heart of the kinetochore is a specialized nucleosome that contains centromere protein (CENP)-A, a histone H3 homologue. Several inner kinetochore components (cyan and purple ovals ...

Scientists have solved a decade-long question about the mechanism that preserves the centromere, the hub that ensures DNA divides correctly during cell division. The study, published in Science ...