This counterintuitive phenomenon, known as overflow metabolism or the Warburg effect, is universal across various organisms. Despite extensive research, its origin and function remain unclear. Here, ...

How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where first it was observed with the ...

More information: Haowen Jiang et al, The Warburg effect drives dedifferentiation through epigenetic reprogramming, Cancer Biology & Medicine (2024). DOI: 10.20892/j.issn.2095-3941.2023.0467 ...

Reprogramming of stromal cell metabolism toward glycolysis in cancerous tissue provides a source of high-energy metabolic intermediates which support proliferation, invasion and metastasis of invading ...