The first study, by Yancopoulos and colleagues, investigated this issue using VEGF Trap (aflibercept), a fully human soluble receptor protein with VEGF receptor 1 (VEGFR1) and VEGFR2 domains ...

It interacts with the receptor tyrosine kinases VEGFR1 and VEGFR2, as well as co-receptors NRP-1 and NRP-2, which enhance VEGFR2 signaling. VEGF165 activates VEGFR1 and VEGFR2 and triggers key ...