Proteins in the cell are subject to diverse covalent modifications that serve to alter their activity, localization, or turnover. Such modifications include ubiquitination and covalent attachment of ...

Defects in ubiquitin–UBD interactions are relevant for development of disease, such as inflammation and cancer. The new structure-based insights provide strategies for the design of new ...

Figure 1: Domain structure of ubiquitin-specific proteases ... Isopeptide versus peptide cleavage. The chemical features of an isopeptide bond differ significantly from those of a peptide bond.

Subsequent work revealed the structural basis for requisite conformational changes through application of chemical probes that mimicked unstable intermediates in the pathway, showing that the E1 ...