For some people, type 2 diabetes can be managed with lifestyle modifications alone (changes in diet and regular exercise). However, typically, type 2 diabetes is treated with medication plus lifestyle ...

Thiazolidinediones (TZDs) are the major drug class used to improve insulin sensitivity in the treatment of type 2 diabetes. However, TZDs have several adverse effects, including weight gain and ...

Patients with type 2 diabetes mellitus (T2DM ... Sulfonylurea treatment was used as a comparator to that of thiazolidinediones because agents of either of these drug classes are usually prescribed ...

2007;64(9):931-936. These favorable effects on cardiovascular surrogate endpoints highlight the TZDs' potential to affect the progression of diabetes and cardiovascular disease but must be weighed ...

Dr Joyce Huang will be joined by Dr Emma Mead to discuss the ways we’re widening the search for new dementia treatments.

Treatment of type 2 diabetes with thiazolidinediones can lead to excess weight gain, but the mechanisms behind this change have been unclear. In September 23 Nature Medicine, Hong-Ping Guan and ...

Accumulating evidence from long-term trials has demonstrated the negative effects of the thiazolidinediones on cardiovascular disease among individuals with type II diabetes. The risk of heart ...