These motifs have been categorized as (i) phosphorylation-based substrate motifs (that is, motifs that are recognized by serine/threonine/tyrosine kinases or phosphatases and (ii) phosphorylation ...

Kinases, enzymes that phosphorylate proteins, generally control the amplitude of a signal response, whereas phosphatases, enzymes that dephopshorylate proteins, are thought to be important for ...

Using a mouse model, Xu and Sun’s team demonstrated that the protein, tyrosine phosphatase SHP2, negatively regulated NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis.

By Dr. Liji Thomas, MD Study reveals how the JAK inhibitor lowers ACE2 expression and viral entry in individuals with a ...

The acquisition bolsters Boehringer's immuno-oncology pipeline with Nerio's new PTPN2/N1 [protein tyrosine phosphatase ...