New research shows that not all brain cells age equally, with certain cells, such as those in the hypothalamus, experiencing ...

Mutations in a gene called OTP cause obesity by controlling the output of another gene already targeted by an anti-obesity drug, a study led by UT Southwestern Medical Center researchers shows. The ...

A small population of GABAergic sleep-active neurons in the ventrolateral preoptic hypothalamus (VLPO) distribute inhibitory inputs to wake-promoting neuronal populations using serotonin (5HT ...

Within the arcuate nucleus (ARC) of the hypothalamus ... expression varies significantly between these neuron types. AGRP/NPY neurons, when lacking LepR, lead to severe obesity, while POMC ...

A mouse study funded by the NIH offers insights into how aging may influence genetic activity in brain cells. New brain ...

By integrating molecular mapping techniques, the researchers identified specific hypothalamic neural circuits and neurons that inhibit the hunger-driving Agouti-related peptide (AgRP) neurons ...

Neuroscientists discover a pathway to restore mobility, leveraging deep brain stimulation to activate key neurons and enable walking recovery for individuals with spinal cord injuries. Study ...

neurons that modulate appetite control. There are projections from the ARC to other hypothalamic nuclei, as well as the cerebral cortex and reward pathways. Multiple neuropeptides have been ...