The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses.

[1] In their report, the authors develop weighted criteria to prioritize tumor vaccine antigens with the goal of identifying rational criteria to move individual antigens forward in development ...

In a recent study published in Nature Biotechnology, researchers describe the molecular structure of targeted recognition ... including tumor-associated antigens or neoantigens, as well as ...

From published reports, a prioritized list ranking 75 tumor-associated vaccine antigens by these criteria is presented. Given the large number of potential tumor vaccine antigens, and the general ...

(2) These cells are activated using anti-CD3/CD28 antibodies to stimulate their proliferation. (3) Genetic modification of the T cells is performed by inserting the CAR gene, enabling them to ...

"We envision that ATLAS-seq can play a pivotal role in identifying TCRs targeting tumor antigens, driving the development of novel T cell immunotherapies ... its unique family-centered care and public ...

Supervised Exercise for Patients With Metastatic Breast Cancer: A Cost-Utility Analysis Alongside the PREFERABLE-EFFECT Randomized ... patients with metastatic CRC often face limited options and poor ...