Mediator—a general transcription factor—may acquire gene-specific functions that are triggered by TF binding. One focus of the lab is to study how TFs regulate Mediator structure and function. To do ...

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA ...

A new study led by Prof. Yosef Buganim from the Hebrew University of Jerusalem and Dr. Abdenour Soufi from the University of ...

"In synthetic biology or gene therapy, transcription factors with off-target effects can cause some concerning unintended consequences, so, by understanding and being able to manipulate mechanisms ...

Researchers from the A*STAR Institute of Molecular and Cell Biology (IMCB), led by Dr Jonathan Yuin-Han Loh, have identified Nr1h2, a critical transcription factor essential for early embryo ...

The findings pave the way for innovative strategies to manipulate gene expression, with profound implications for regenerative therapies and developmental biology. The research, titled “Nucleosome ...