Well, the answer isn't as straightforward as you might think. The Devil card, like all tarot cards, holds a complex set of meanings that shift depending on its position, the surrounding cards ...
Human beings are not free in what they do because they are not free in what they want, such is the meaning of this card. The reversed Devil represents freedom and breaking the chains that trap you.
Villains in stories are complex characters, and tarot cards like The Devil, The Emperor, The Tower, and The Magician can represent their traits. Thanos parallels The Devil, Vader fits The Emperor ...