The transforming growth factor beta (TGF-beta) pathway regulates vascular remodeling and mutations in its receptor genes, TGFBR1 and TGFBR2, cause syndromes with thoracic aortic aneurysm (TAA).
BAG-1 is a modulator of NF-kappa B signaling; this has implications for the regulation of a number of important pro-survival factors including the COX-2/prostaglandin, EGF and TGF-beta ...
Jefferies initiated coverage of Keros Therapeutics (KROS) with a Buy rating and $107 price target The firm says Keros has expertise in the TGF-beta pathway, which plays roles in blood, lung and ...