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SUMO2/3-ylation:守护 TDP-43 的 “隐形卫士”,对抗神经退行性疾病的新 ...
为探究细胞如何调控 TDP-43 聚集这一难题,研究人员开展关于 TDP-43 SUMO2/3-ylation 的研究,发现其可稳定胞质无 RNA 的 TDP-43,这为相关疾病治疗提供新思路。 在神经退行性疾病的神秘领域中,肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)和额颞叶痴呆 ...
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