Furthermore, they have demonstrated that it is possible to reprogram other cancer cells to become dependent on this enzyme – called transforming growth factor beta-activated kinase 1 (TAK1) – which ...

It is a key kinase in innate immunity that integrates and controls signaling and production of key pathological cytokines. TAK1 integrates clinically and genetically validated pathways in human ...

TAK1 is a key mediator of human inflammatory bowel diseases (IBD) through the NF-kB pathway. Here, the authors show that TAK1 phosphorylates TRADD, which cooperates with RIPK1 to intestinal ...