The spindle-assembly checkpoint contributes ... of mitosis begin in anaphase, when the mitotic spindle segregates the duplicated chromosomes. Mitotic exit is then completed by disassembly of ...

Aneuploidy is primarily caused by errors during mitosis. In normal cells, correct segregation of chromosomes is ensured by an evolutionarily conserved surveillance signal transduction pathway called ...

During mitosis, the spindle fibers are called the mitotic spindle ... The cell goes through an important checkpoint to ensure that all of the chromosomes are attached to the spindle and ready ...

The spindle assembly checkpoint is a safeguard mechanism that is crucial for maintaining genomic stability by arresting cell division until all the chromosomes are correctly attached to the mitotic ...