This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Zhang and his colleagues designed a generative AI model called ChromoGen to quickly ‘read’ DNA sequences and predict the ...

This method can be used on large populations of cells to calculate an average structure for a section of chromatin, or on single cells to determine structures within that specific cell.

Chromatin remodelers play a key role in regulating access to DNA (which is packed within the cell into chromatin ... at NUS ...

More information: Greg Schuette et al, ChromoGen: Diffusion model predicts single-cell chromatin conformations, Science Advances (2025). DOI: 10.1126/sciadv.adr8265 Journal information: Science ...

We specialize in utilizing single-cell multi-omics approaches that profile multiple orthogonal properties of the same cells, including cell state (i.e. accessible chromatin, RNA, and protein) as well ...

In a first, aging-related gene expression changes in breast tissues are linked to alterations in chromatin accessibility.

The chromatin-bound proteome of embryonic stem cells transitioning to 2C-like cells uncovers chromatin regulators involved in heterochromatin formation.

Inspired by the UV light-based immunochemical approach developed by Lis and Gilmour, the team decided to use antibodies to capture a histone of interest, in this case histone 4 (H4), one of the ...