Efficient RNA interference in Caenorhabditis elegans requires a distinct class of secondary short interfering RNA. Although many proteins involved in RNAi were initially studied in the context of ...

Aro Biotherapeutics, a clinical-stage biotechnology company working to develop potent, targeted short-interfering RNA (siRNA) ...

Figure 1: Short interfering RNAs are at the heart of RNA interference. Figure 3: MicroRNAs and short interfering RNAs might use the same RNA-processing complex to direct silencing. When RNAi was ...

View Full Profile. Learn about our Editorial Policies. The natural RNAi mechanism can be directed by either short interfering RNA (siRNA) or microRNA (miRNA). 1 There are four key steps in the RNAi ...

The company has already kicked off an open-label Phase I trial of ABX1100 in Canada following positive results from a study of healthy volunteers.

Behrens' team faced this problem several years ago when they sought to use short RNA molecules (siRNA) to optimize a similar process in plants known as RNA interference. At the time, the ...