In fever the balance between heat production and heat loss persists, except that the "thermostat" is set at a higher level. Salicylate acts to reset the "thermostat" at a normal temperature.

Serum was collected at 10:00 11:00 am (4 5 h after lights were turned on). Serum salicylate levels of aspirin-, sodium salicylate , and sulfasalazine-treated rats were 0.037 ± 0.023 ...