SRP was first identified in mammalian cells in the early 1980s as a soluble complex of six polypeptides and a 300 nucleotide RNA that targets proteins to the endoplasmic reticulum (ER) 2.The 54 ...

This latter targeting system makes use of cpSRP54 together with a distinct cpSRP43 protein, but lacks the conserved SRP RNA of the bacterial and cytosolic SRPs. So how does the cpSRP work without ...