Our data suggest that enhanced RyR2 activity is caused by altered levels of `Striated Muscle Preferentially Expressed Protein Kinase' (SPEG) in atria of patients and mice with poAF. The long-term goal ...

We are particularly interested in the genetic and posttranslational regulation of key molecules involved in intracellular calcium handling, including the ryanodine receptor type 2 (RyR2), striated ...