New antibiotics must overcome resistance mechanisms using more efficient ... In the early 1990s, Shionogi identified two siderophore cephalosporins with potent antibacterial activity against ...

VEB-1 A 2br Penicillins Resistance to clavulanic acid, sulbactam and tazobactam TEM-30, SHV-10 A 2ber Extended-spectrum cephalosporins, monobactams Increased hydrolysis of oxyimino-β-lactams ...

regimen of cephalosporins. In addition, the clinical outcomes (mortality and clinical cure) and the secondary outcomes (adverse events and emergence of resistance) in each treatment group were ...