Long-term post-stroke cognitive dysfunction in aged subjects may be associated with increased synapse pruning by astrocytes, as increased reactive astrocytes are present in and around the atrophic ...

Heterogeneous astrocytes have specific activities in the healthy brain, and respond differently to physiological or pathological stimuli, such as inflammaging present in normal brain aging or ...

However, during the onset and progression of PD, astrocytes are converted into reactive astrocytes; during this process, the astrocytes undergo proliferation, hypertrophy and produce a variety of ...

“Understanding that if we could mimic at least certain aspects of that with our culture platform, it might allow us to mechanistically identify why the cells were transitioning to one particular ...

White matter injury (WMI) produces a cascade of cellular responses that contribute to both pathogenesis and recovery, including the generation of reactive astrocytes. Using our developmental studies ...

This impairment occurs in peri-infarct tissue that otherwise looks healthy but displays changes in astrocyte morphology and expression patterns suggesting reactive astrogliosis. The functional ...

Meanwhile, 3-HKA inhibits the activation of neurotoxic (A1-like) astrocytes but promotes the polarization of neuroprotective (A2-like) astrocytes. Mechanistically, 3-HKA inhibited the activation of ...

"Homeostatic astrocytes, which maintain brain synaptic function, declined in regions with advanced AD neuropathology whereas reactive, disease-associated astrocytes increased in proportion." ...

Augmentation of acetate uptake, mediated by MCT1, facilitates Aβ-induced GABA release in reactive astrocyte. A. Blockade effect of MCT1 inhibitor on 14C-acetate uptake in primary cultured astrocytes.