Of particular importance is the balance between RANKL (the ligand for a membrane-bound osteoclast receptor [RANK] that initiates osteoclastic bone resorption), RANK (receptor activator for nuclear ...

长期使用糖皮质激素会对骨骼健康产生显著影响，其中糖皮质激素诱导的骨质疏松症（GIOP）是最为常见的后果。此前研究表明，苍术内酯 I（Atractylenolide I，Atr I）具有抗炎、抗氧化和抗肿瘤特性，然而其对破骨细胞生成以及 GIOP 的具体作用仍不明确。在本研究中，体外实验结果显示，Atr I 以剂量依赖的方式抑制核因子 κB 受体活化因子配体（RANKL）刺激的破骨细胞分化，破坏成熟 ...

No writing assistance was utilized in the production of this manuscript. RANKL expression is stimulated in osteoblasts and osteocytes by cytokines and hormones, and plays an important role in ...

Prolia works differently from Evenity by binding to a different protein called RANK ligand (RANKL). RANKL is essential for ...