Receptor tyrosine kinases (RTKs) are pivotal in both normal cellular functions and cancer progression, activating critical signaling pathways. In cancer therapy, targeted therapies using monoclonal ...

RTKs can activate Ras, a protein that is tethered to the plasma membrane, by causing it to bind GTP. Once activated, Ras can do a variety of things. In this example, it activates an enzymatic ...

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?