Widespread alterations in RNA processing (splicing, polyadenylation, decay, etc.) are common in dynamic cell states during development and malignancy. For example, many cancers harbor elevated levels ...

Alternative pathways of RNA processing are regulated in response to signaling cues often coordinating expression of gene networks in response to physiological change including in development and ...

Splicing is a processing event in which non-coding segments ... It is well established that such aberrant splicing of RNA can generate unusual and at times ‘nonsensical’ proteins.

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

molecule during RNA processing to increase the stability of the molecule. Immediately after a gene in a eukaryotic cell is transcribed, the new RNA molecule undergoes several modifications known ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies protein synthesis and impacts RNA processing in Alzheimer's ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

miRecule, a biotechnology company focusing on RNA therapies, and GBI Biomanufacturing, a CDMO, partnered to advance the development and clinical supply of miRecule’s Antibody-RNA Conjugate (ARC ...