The team observed a 4.4-fold increase in the editing efficiency of this modified nuclease, surpassing most of the commonly used RNA-guided endonucleases, including CjCas9. They called this variant ...

Wulf Blankenfeldt at HZI. "The nuclease Cas13b can recognize and cut RNA. It is currently used to silence genes, whether to study their function, clear viruses, or counteract genetic diseases ...

are prototypal RNA healing and sealing enzymes. They function in vivo to repair a break in E. coli tRNA Lys triggered by phage-activation of a latent host-encoded anticodon nuclease PrrC. PrrC ...

In one, we studied the structure and mechanism of activity of the catalytic RNA moiety of the RNA processing enzyme ribo-nuclease P (Rnase P). In the second, we explored naturally occurring ...

“...RNA granule-mediated post-transcriptional and epigenetic alterations in protein expression are remnants of an ancient RNA world...” An important consequence ...

DNA can be duplicated or read to produce RNA, which is translated to generate protein. So ran the 'central dogma' of biology, devised by Francis Crick in 1958 to explain the directional flow of ...

We have solved the cryo-EM structure of AcrVIA1 bound to Cas13a crRNA, establishing that AcrVIA1 interacts with the guide-exposed face of Cas13a, thereby preventing access to the target RNA and the ...

The firm will use the funds to develop its lead candidate in primary hyperoxaluria type 1 and other pipeline products in liver and CNS disorders.

To safeguard DNA and RNA from nonspecific cleavage by these molecular scissors, our cells support elegant mechanisms of regulation to ensure nucleases cut precisely. To uncover the mechanisms for ...