Hybridize the DNA and RNA at the chosen temperature for 12–16 h. 13. Keeping the body of the tube submerged, open the lid of the hybridization tube. Rapidly add 300 μl of ice-cold nuclease S1 ...

The nuclease Cas13b can recognize and cut RNA. It is currently used to silence genes, whether to study their function, clear viruses or counteract genetic diseases linked to the gene.” ...

Our laboratory carried out research in two areas. In one, we studied the structure and mechanism of activity of the catalytic RNA moiety of the RNA processing enzyme ribo-nuclease P (Rnase P). In the ...

The team observed a 4.4-fold increase in the editing efficiency of this modified nuclease, surpassing most of the commonly used RNA-guided endonucleases, including CjCas9. They called this variant ...

Chase Beisel, who led the study together with the department of Prof. Wulf Blankenfeldt at HZI. “The nuclease Cas13b can recognize and cut RNA. It is currently used to silence genes, whether to study ...

Wulf Blankenfeldt at HZI. “The nuclease Cas13b can recognize and cut RNA. It is currently used to silence genes, whether to study their function, clear viruses, or counteract genetic diseases li ...

“The RNA Gene Writer protein goes to the genome [and] nicks one strand ... He also adds that those researchers typically avoided the headache by linking the transposon to a precision-boosting nuclease ...

We have solved the cryo-EM structure of AcrVIA1 bound to Cas13a crRNA, establishing that AcrVIA1 interacts with the guide-exposed face of Cas13a, thereby preventing access to the target RNA and the ...

LETI-101 has demonstrated therapeutically relevant reductions of mutant huntingtin (HTT) protein, exceeding 80%, while preserving essential ...

GMP Salt Active GENIUS ™ Nuclease is developed using ACROBiosystems' unique enzyme AI evolution platform, based on wild-type Serratia marcescens endonuclease. It maintains high specific activity ...