As well as degrading proteins, the proteosome surprisingly also functions in human defence against bacterial infection. By ...

We believe that the ubiquitin/proteasome pathway is involved in so many cellular processes that it could not be properly described by a single model substrate and that the minimal requirement ...

E1s and E2s first work generically across the cell to activate and prepare ubiquitin for attachment. E3 ligases then ensure that the tag is added to the right protein; as such, hundreds of specific ...