Protein aggregation is typical of neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team headed by Professor Jörg Tatzelt from ...

Lipid anchors on nerve cell membranes stabilize prion protein folding, inhibiting aggregation. Membrane-anchored proteins clump only when exposed to pre-formed protein aggregates, simulating ...

3D reconstruction of a microscope image: red is the membrane and green is clumped prion protein. In order to gain new insights into the underlying processes, the researchers have developed new ...

A research team has now used new in vitro and cell culture models to show that a lipid anchor on the outer membrane of nerve cells inhibits the aggregation of the prion protein. Researchers have ...

A recent paper reported the in vitro generation of new prion strains, supporting the idea that 'strain-ness' is encoded in the protein structure itself. This lays the groundwork for a ...

A system for the rapid amplification of misfolded prion oligomers provides new evidence supporting the prion hypothesis and may offer a powerful diagnostic tool. The prion hypothesis remains ...

The treatment, ... A study from Bochum describes a mammal-specific domain of the prion protein and offers new approaches for research into neurodegenerative diseases. A new study of prion diseases ...

Dr. Yee's group published the first crystal structure of the human prion protein, whose conformational transformation to a pathogenic form is believed to be important in an intriguing family of ...

Explorations of toxic protein species via genetic disease ... If so, PrP C contributes to neurotoxicity in prion disease but by uncertain mechnisms.