这项研究意义重大，它为转录调控机制提供了新的见解，揭示了 RPB7 和 CTDP1 在 Pol II 转录终止和重新起始过程中的关键作用。这不仅有助于我们更深入地理解细胞内基因表达的调控机制，也为相关疾病的研究和治疗提供了潜在的靶点。然而，目前仍有许多问题有待进一步探索，例如 CTDP1 在染色质和可溶性核质中的底物特异性，以及 CUL3 如何区分超磷酸化和低磷酸化的 Pol II ...

癌蛋白ANLN调节有丝分裂过程中的收缩环组装，已被报道为癌蛋白。在这里，作者报道了核ANLN通过与RNA Pol II相互作用并促进其聚类和相分离在基因转录调控中的作用。 核内 ANLN 调控转录起始相关的 Pol II 聚集及靶基因表达研究解读 汕头大学医学院分子生物学重点 ...

mRNA transcription by RNA polymerase II (Pol II) is rapidly regulated in response to many different types of cellular stress, including heat shock. In response to heat shock in human cells, several ...

Focusing on yeast, there are ∼ 20,000 molecules of Pol II in cells of S. cerevisiae 5.Of these, ∼ 60% are hyperphosphorylated on the C-terminal domain and associated with chromatin in a salt ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

The process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.

Thus, it is RNA pol II that transcribes the messenger RNAs, which serve as the templates for production of protein molecules. The first step in transcription is initiation, when the RNA pol binds ...

Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in ...