Still, BLT- or FLC-humanized mice have some limitations (difficulties ... myeloid cells and essentially no human erythrocytes or platelets. This bias is explained in part by the fact that the ...

If on hearing “humanized mouse” you think Stewart Little, your imagination has taken you a bit too far. Imagine instead a mouse with a human gene. The goal of humanizing a mouse is to model ...

Ray Lambert looks at the potential of humanized FcRn mice for evaluating the pharmacokinetics of mAbs. Due to their extraordinary specificity and pharmacokinetic (PK) behavior, human ...

A key finding from these studies was that platelets from mice lacking certain isoforms of the serine/threonine kinase Akt (particularly Akt2) have defects in platelet secretion, fibrinogen binding, ...