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生物通
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Sirt1 通过 PHD3/HIF-1α 通路减轻心肌梗死中缺氧诱导的心肌细胞凋亡 ...
急性心肌梗死(AMI)是全球心血管疾病患者的主要死因,就像一颗随时可能引爆的 “定时炸弹”,严重威胁着人们的生命健康。它的病理过程主要是心肌缺血,进而引发缺氧,这会导致心肌细胞凋亡和坏死,最终造成心脏功能受损。在这个复杂的病理过程中,Sirtuin 1(Sirt1)作为细胞存活和凋亡的关键调节因子,却一直 “深藏不露”,其与 AMI 之间的关系尚不明确。而且,缺氧诱导因子 - ...
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