The solution structure of the dNumb phosphotyrosine ... At the same time the IRS-1 pleckstrin homology domain (PH) binds to phosphoinositides in the plasma membrane. The IR bound IRS-1 is then ...

These signals synergize to release the autoinhibitory DH-PH domain, while the histone domain fine-tunes SOS activation in response to PIP 2. External signals stimulate pathways that control ...