Perineural involvement is a well-recognized clinicopathologic entity found in head and neck (H&N) cancers, including mucosal epithelial carcinomas and salivary gland malignancies. Perineural ...

Perineural invasion (PNI) is a histopathologic diagnosis, while perineural spread (PNS) is a clinical and radiologic diagnosis. PNI in head and neck cancers is well described, and the available ...

It can also help determine if the cancer may have spread beyond the prostate gland, such as near the nerves. In that case, the biopsy will show that there's perineural invasion. "Perineural ...