The same kind of prion-like seeding and spreading may ... may modulate Alzheimer's disease pathogenesis as well via the microglia, the review in Cell explained. An underlying infectious basis ...

iPSC-derived neurons can provide important mechanistic insights into the pathogenesis of genetic prion diseases, and can offer a powerful platform for testing candidate therapeutics," said co ...

Prion diseases are characterized by abnormal folding of the host ... that mimics some of the underlying pathophysiology. While genetic factors can increase or decrease the risk of common ...

Dr. Patricia Aguilar Calvo's laboratory focuses on the factors that modulate the interaction of misfolded proteins with glycoproteins and the impact in the pathogenesis of prion and Parkinson's ...

The National Prion Disease Pathology Surveillance Center (NPDPSC) was established in 1997 at the Division of Neuropathology of Case Western Reserve University. Several European countries also have ...

Prion Disease is currently an invariably fatal condition without treatment or cure. Despite multiple prior treatment studies, including quinacrine, doxycycline, and pentosan polysulfate, no ...

and Creutzfeldt–Jakob disease (CJD) in humans. In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for ...