During homeostasis, the ISC niche exists in the crypt together with differentiated cells (e.g., lysozyme producing Paneth cells in the small intestine) and stromal cells at the underlying mesenchyme.

Paneth cells seem to be central for the development of small intestinal CD. Antimicrobial defensins, especially Paneth cell defensins, regulate the composition of the bacterial flora. Chemokines ...

A new study published in Cell shows that a dysregulated response to endoplasmic reticulum (ER) stress can lead to organ-specific inflammation, and that hypomorphic variants of X-box-binding ...