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综述:TIGIT/PVR 轴在血液系统恶性肿瘤中调节抗肿瘤免疫
TIGIT 的结构与表达 TIGIT 又称 WUCAM、Vstm3 和 VSIG9,是一种共抑制受体,属于不断扩展的 PVR 样蛋白家族。它由细胞外免疫球蛋白(Ig)可变域、I 型跨膜域以及含有免疫受体酪氨酸抑制基序(ITIM)和 Ig 尾酪氨酸(ITT)样基序的细胞内域构成。TIGIT 在淋巴细胞(NK ...
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