The cycle progression is extensively controlled by the pRB/E2F signaling pathway. E2F is released from the pRB/E2F complex with the phosphorylation of pRB by cyclin–cyclin-dependent kinase (CDK ...

A multistep pathway, involving phosphorylation of pRB by cyclin-dependent kinases and release of E2F transcription factors required for DNA synthesis, culminates in progression from the G 1 to the ...

and resulting in the E2F-mediated stimulation of genes involved in the G1 → S transition. The E7 proteins of high-and low-risk HPV strains share a specific amino acid difference in their pRb ...

The product of this tumor suppressor gene, a 105-kilodalton polypeptide called pRB, `is a cell cycle regulator. The pRB polypeptide inhibits cell proliferation by arresting cells at the G1 phase of ...