The cycle progression is extensively controlled by the pRB/E2F signaling pathway. E2F is released from the pRB/E2F complex with the phosphorylation of pRB by cyclin–cyclin-dependent kinase (CDK ...

细胞周期调节因子的适当调控对于病毒复制和宿主植物适应性生长在病毒感染过程中至关重要。然而，宿主-病毒相互作用中重新编排视网膜母细胞瘤相关蛋白1（RBR1，E2F转录因子的抑制因子）及其下游基因的机制尚不清楚。 细胞分裂周期20（CDC20）通过E2F转录 ...

and resulting in the E2F-mediated stimulation of genes involved in the G1 → S transition. The E7 proteins of high-and low-risk HPV strains share a specific amino acid difference in their pRb ...

The product of this tumor suppressor gene, a 105-kilodalton polypeptide called pRB, `is a cell cycle regulator. The pRB polypeptide inhibits cell proliferation by arresting cells at the G1 phase of ...